o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester

Base Information

• Chemical Name: o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester
• CAS No.: 914930-45-3
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.322
• Mol file: 914930-45-3.mol

Synonyms:o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester

Chemical Property of o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester

There total 1 articles about o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

monoethyl phthalate (2306-33-4) + α-bromoacetophenone (70-11-1) → o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester (914930-45-3)

Guidance literature:

With triethylamine; In acetone; for 3h; Heating;

DOI:10.3987/COM-06-10757

Reference yield: 72.0%

o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester (914930-45-3) → 3-benzoyl-4-hydroxyisochromen-1-one (914930-55-5)

Guidance literature:

With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; at 25 ℃; for 3.5h;

DOI:10.3987/COM-06-10757

Reference yield:

o-phthalic acid 1-ethyl ester 2-(2-oxo-2-phenylethyl) ester (914930-45-3) → acetic acid 3-benzoyl-1-oxo-1H-isochromen-4-yl ester (914930-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / KOH / 1-methyl-pyrrolidin-2-one / 3.5 h / 25 °C

2: 99.3 percent / p-toluenesulfonic acid / 3 h / Heating

With potassium hydroxide; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one;

DOI:10.3987/COM-06-10757

upstream raw materials:

monoethyl phthalate

α-bromoacetophenone

Downstream raw materials:

3-benzoyl-4-hydroxyisochromen-1-one

acetic acid 3-benzoyl-1-oxo-1H-isochromen-4-yl ester

2,6-dioxo-4-phenyl-2,6-dihydropyrano[3,2-c]isochromene-3-carboxylic acid ethyl ester