4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

Base Information

Chemical Name:4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate
CAS No.:1431507-36-6
Molecular Formula:C₆H₈O₇*C₂₇H₂₉N₅O₆S
Molecular Weight:743.748
Hs Code.:

Synonyms:4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

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Chemical Property of 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

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Technology Process of 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

There total 5 articles about 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147536-97-8,174227-18-0
bosentan

: 77-92-9,906507-37-7
citric acid

: 1431507-36-6
4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

Guidance literature:: In acetonitrile; at 20 ℃; for 8h;

Reference yield:

: 7388-28-5,10604-71-4,24768-69-2,26915-75-3,50856-01-4,92004-30-3
sodium 2-hydroxyethoxide

: 77-92-9,906507-37-7
citric acid

: 150727-06-3
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

: 1431507-36-6
4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

Guidance literature:: sodium 2-hydroxyethoxide; 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide; In ethylene glycol; at 110 - 115 ℃; for 5h;

citric acid; In acetonitrile; at 20 ℃; for 8h;

Reference yield:

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 1431507-36-6
4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 120 °C / Inert atmosphere

2.1: ethylene glycol / 5 h / 110 - 115 °C

2.2: 8 h / 20 °C

With potassium carbonate; In ethylene glycol; dimethyl sulfoxide;