7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde

Base Information

• Chemical Name: 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde
• CAS No.: 870094-82-9
• Molecular Formula: C₁₈H₁₈O₇
• Molecular Weight: 346.337
• Mol file: 870094-82-9.mol

Synonyms:7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde

Chemical Property of 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde

There total 5 articles about 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3,4,5-trimethoxyphenylboronic Acid (182163-96-8) + 6-bromo-7-methoxybenzo[d][1,3] dioxole-5-carbaldehyde (795278-07-8) → 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde (870094-82-9)

Guidance literature:

With sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; water-d2; at 60 ℃; for 22h;

DOI:10.1021/jo701415m

Reference yield:

[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol (870094-81-8) → 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde (870094-82-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/anie.200501890

Reference yield:

7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester (870094-80-7) → 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde (870094-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / BH₃*THF / tetrahydrofuran / 14 h / Heating

2: MnO₂ / CH₂Cl₂ / 2 h / 20 °C

With manganese(IV) oxide; borane-THF; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.200501890

upstream raw materials:

[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol

3,4,5-trimethoxyphenylboronic Acid

6-bromo-7-methoxybenzo[d][1,3] dioxole-5-carbaldehyde

7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester

Downstream raw materials:

5-[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]-4-methyl-5H-furan-2-one

eupomatilone-3