4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

Base Information

Chemical Name:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile
CAS No.:1436405-50-3
Molecular Formula:C₂₄H₁₆ClN₅O₃
Molecular Weight:457.876
Hs Code.:

Synonyms:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

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Chemical Property of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

Chemical Property:

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Technology Process of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

There total 9 articles about 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1436405-49-0
4-chloro-5-(4-nitrophenyl)nicotinonitrile

: 524955-09-7
3-chloro-4-(2-pyridylmethoxy)aniline

: 1436405-50-3
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

Guidance literature:: With pyridine hydrochloride; In 1,2-dimethoxyethane; for 5h; Reflux;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 1436405-50-3
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 1 h / Reflux

2.1: sodium ethanolate / ethanol / 1 h / 50 °C

2.2: 1 h / 0 °C

3.1: water / dimethyl sulfoxide / 1 h / 110 °C

4.1: toluene / 6 h / Reflux

4.2: 2 h / Reflux

5.1: trichlorophosphate; lithium chloride / 3 h / Reflux

6.1: pyridine hydrochloride / 1,2-dimethoxyethane / 5 h / Reflux

With thionyl chloride; water; sodium ethanolate; pyridine hydrochloride; lithium chloride; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 1436405-47-8
ethyl 2-cyano-4-(4-nitrophenyl)-3-oxobutanoate

: 1436405-50-3
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-(4-nitrophenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: water / dimethyl sulfoxide / 1 h / 110 °C

2.1: toluene / 6 h / Reflux

2.2: 2 h / Reflux

3.1: trichlorophosphate; lithium chloride / 3 h / Reflux

4.1: pyridine hydrochloride / 1,2-dimethoxyethane / 5 h / Reflux

With water; pyridine hydrochloride; lithium chloride; trichlorophosphate; In 1,2-dimethoxyethane; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2013.03.053