1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene

Base Information

• Chemical Name: 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene
• CAS No.: 100679-74-1
• Molecular Formula: C₄₂H₆₄O₂S
• Molecular Weight: 633.035
• Mol file: 100679-74-1.mol

Synonyms:1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene

Chemical Property of 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene

There total 11 articles about 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E,6E)-3,7,11-trimethyl-1-(p-tolylsulfonyl)dodeca-2,6,10-triene (68690-45-9,80370-68-9,53254-63-0) → 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene (100679-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -65 deg C, 2 h, 2.) -65 deg C, 1 h

2: 79 percent / Li, EtNH₂ / diethyl ether / 1 h / -78 °C

3: MeSO₂Cl, LiCl, s-collidine / dimethylformamide

4: dimethylformamide / 14 h / 60 °C

With 2,4,6-trimethyl-pyridine; n-butyllithium; lithium; ethylamine; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/c39860001761

Reference yield:

(2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-heptamethyltriaconta-2,6,10,14,18,22,26-heptaen-1-ol (5905-41-9,13476-39-6,32247-55-5,32304-16-8,81338-25-2,89577-07-1,96647-65-3,102043-79-8) → 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene (100679-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: MeSO₂Cl, LiCl, s-collidine / dimethylformamide

2: dimethylformamide / 14 h / 60 °C

With 2,4,6-trimethyl-pyridine; methanesulfonyl chloride; lithium chloride; In N,N-dimethyl-formamide;

DOI:10.1039/c39860001761

Reference yield:

(2Z,6Z)-8-(benzyloxy)-2,6-dimethyl-1-(tetrahydropyran-2-yloxy)-octa-2,6-diene (86636-47-7) → 1-((2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-octacosa-2,6,10,14,18,22,26-heptaene-1-sulfonyl)-4-methyl-benzene (100679-74-1)

Guidance literature:

Multi-step reaction with 10 steps

1: 89 percent / Na, NH₃ / 0.17 h / -60 °C

2: MeSO₂Cl, LiCl, s-collidine / dimethylformamide / 2 h / 0 °C

3: dimethylformamide / Ambient temperature

4: 85 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -70 °C

5: 91 percent / p-MeC₆H₄SO₂OH / methanol / 5 h / Ambient temperature

6: 87 percent / MeSO₂Cl, LiCl, s-collidine / dimethylformamide / 4 h / 0 °C

7: 92 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -65 deg C, 2 h, 2.) -65 deg C, 1 h

8: 79 percent / Li, EtNH₂ / diethyl ether / 1 h / -78 °C

9: MeSO₂Cl, LiCl, s-collidine / dimethylformamide

10: dimethylformamide / 14 h / 60 °C

With 2,4,6-trimethyl-pyridine; n-butyllithium; ammonia; sodium; lithium; toluene-4-sulfonic acid; ethylamine; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/c39860001761

upstream raw materials:

sodium 4-methylbenzenesulfinate

(2E,6E)-3,7,11-trimethyl-1-(p-tolylsulfonyl)dodeca-2,6,10-triene

(2Z,6Z)-8-(benzyloxy)-2,6-dimethyl-1-(tetrahydropyran-2-yloxy)-octa-2,6-diene

(2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-heptamethyltriaconta-2,6,10,14,18,22,26-heptaen-1-ol