dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Base Information

Chemical Name:dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine
CAS No.:1198109-27-1
Molecular Formula:C₂₁H₂₃F₂N₅O
Molecular Weight:399.443
Hs Code.:

Synonyms:dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

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Technology Process of dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

There total 3 articles about dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1198109-66-8
N-dicyclopropylmethyl-(2,8-dimethyl-9H-purin-6-yl)-amine

: 104197-14-0
5-bromo-1,3-difluoro-2-methoxy-benzene

: 1198109-27-1
dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1198109-65-7
1-(6-chloro-2,8-dimethyl-purin-9-yl)-ethanone

: 1198109-27-1
dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; cesium fluoride / dimethyl sulfoxide / 3 h / 150 °C

2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 130 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1198109-27-1
dicyclopropylmethyl-[9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / water / 70 - 100 °C

2.1: 4.33 h / 20 - 110 °C / Inert atmosphere

2.2: 0.08 h / 90 °C

3.1: N-ethyl-N,N-diisopropylamine; cesium fluoride / dimethyl sulfoxide / 3 h / 150 °C

4.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 130 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; 1,10-Phenanthroline; ammonia; caesium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;