8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine

Base Information

• Chemical Name: 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine
• CAS No.: 1361022-24-3
• Molecular Formula: C₂₄H₂₆O₅
• Molecular Weight: 394.467
• Mol file: 1361022-24-3.mol

Synonyms:8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine

Chemical Property of 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine

There total 3 articles about 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C21H22O4 (1360827-52-6) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine (1361022-24-3)

Guidance literature:

With triethylamine; Reflux;

DOI:10.1016/j.bmcl.2012.01.009

Reference yield:

2-sec-butylphenol (89-72-5) → 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine (1361022-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 3 h / 120 °C

1.2: 2 h / 90 - 100 °C

2.1: hydrogenchloride / 1,4-dioxane / 80 - 90 °C

3.1: triethylamine / Reflux

With hydrogenchloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; 1.1: Duff reaction / 1.2: Duff reaction;

DOI:10.1016/j.bmcl.2012.01.009

Reference yield:

5-(sec-butyl)-4-hydroxybenzene-1,3-dicarbaldehyde (1257865-15-8) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 8-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl),10-sec-butyl 3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine (1361022-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 80 - 90 °C

2: triethylamine / Reflux

With hydrogenchloride; triethylamine; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2012.01.009

upstream raw materials:

2-sec-butylphenol

5-(sec-butyl)-4-hydroxybenzene-1,3-dicarbaldehyde

1-(4-methoxyphenyl)ethanone

C₂₁H₂₂O₄