tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate

Base Information

• Chemical Name: tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate
• CAS No.: 1374511-00-8
• Molecular Formula: C₂₀H₂₂N₂O₂S
• Molecular Weight: 354.473
• Mol file: 1374511-00-8.mol

Synonyms:tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate

Chemical Property of tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate

There total 1 articles about tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloromethyl-1H-benzimidazole (4857-04-9) → tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate (1374511-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / 2 h / Reflux

1.2: 0.5 h / 20 °C

2.1: potassium carbonate / acetone / 6 h / 20 °C

With potassium carbonate; In acetone;

DOI:10.1016/j.bmcl.2012.03.061

Reference yield: 75.0%

tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate (1374511-00-8) → C16H16N4OS (1374511-01-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 7h;

DOI:10.1016/j.bmcl.2012.03.061

Reference yield:

tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate (1374511-00-8) → N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-02-0) + N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 7 h / 20 °C

2: acetic acid / ethanol / 2 h / 90 °C

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2012.03.061

upstream raw materials:

2-chloromethyl-1H-benzimidazole

Downstream raw materials:

N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

N'-(4-methoxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

N'-(4-methoxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide