(4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

Base Information

Chemical Name:(4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid
CAS No.:917023-29-1
Molecular Formula:C₃₄H₄₃FO₃
Molecular Weight:518.712
Hs Code.:

Synonyms:(4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

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Chemical Property of (4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

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Technology Process of (4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

There total 3 articles about (4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)-acetic acid methyl ester

: 917023-29-1
(4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

Guidance literature:: (4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)-acetic acid methyl ester; With sodium hydroxide; water; In methanol; at 20 ℃; for 6h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 194240-75-0
2-(4-chloro-2-fluorophenyl)acetic acid

: 917023-29-1
(4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 0 - 20 °C

2: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 1 h / 96 - 104 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: sodium hydroxide; water / methanol / 6 h / 20 °C

With sodium hydroxide; potassium phosphate; thionyl chloride; water; trifluoroacetic acid; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In methanol; dichloromethane; water; toluene;

Reference yield:

: 917023-04-2
methyl 2-(4-chloro-2-fluorophenyl)acetate

: 917023-29-1
(4'-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 1 h / 96 - 104 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: sodium hydroxide; water / methanol / 6 h / 20 °C

With sodium hydroxide; potassium phosphate; water; trifluoroacetic acid; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In methanol; dichloromethane; water; toluene;