methyl 2-(4-chloro-2-fluorophenyl)acetate

Base Information

• Chemical Name: methyl 2-(4-chloro-2-fluorophenyl)acetate
• CAS No.: 917023-04-2
• Molecular Formula: C9H8ClFO2
• Molecular Weight: 202.613
• Mol file: 917023-04-2.mol

Synonyms:methyl 2-(4-chloro-2-fluorophenyl)acetate;methyl (4-chloro-2-fluorophenyl)acetate

Chemical Property of methyl 2-(4-chloro-2-fluorophenyl)acetate

Chemical Property:

• Boiling Point: 236.1±25.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.279±0.06 g/cm3(Predicted)
• LogP: 2.19460

Purity/Quality:

98% ^*data from raw suppliers

Methyl 2-(4-chloro-2-fluorophenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(4-chloro-2-fluorophenyl)acetate

There total 1 articles about methyl 2-(4-chloro-2-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 2-(4-chloro-2-fluorophenyl)acetic acid (194240-75-0) → methyl 2-(4-chloro-2-fluorophenyl)acetate (917023-04-2)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

Reference yield: 81.0%

methyl 2-(4-chloro-2-fluorophenyl)acetate (917023-04-2) + 2-(4-{1-ethyl-1-[3-methyl-4-(1-trimethylsilanyloxy-cyclopentylethynyl)-phenyl]-propyl}-2-methyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (917024-88-5) → (4'-{1-ethyl-1-[3-methyl-4-(1-trimethylsilanyloxy-cyclopentylethynyl)-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)-acetic acid methyl ester (917025-63-9)

Guidance literature:

With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In water; toluene; at 100 ℃; for 1h;

Reference yield: 77.0%

methyl 2-(4-chloro-2-fluorophenyl)acetate (917023-04-2) + t-butyl-(1-{2-[4-(1-ethyl-1-{4-[4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl]-3-methyl-phenyl}-propyl)2-methyl-phenyl]-ethyl}-2,2-dimethyl-propoxy)dimethylsilane (917024-83-0) → [4'-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester (917025-32-2)

Guidance literature:

With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In water; toluene; at 96 - 104 ℃; for 1h;

upstream raw materials:

methanol

2-(4-chloro-2-fluorophenyl)acetic acid

Downstream raw materials:

methyl 2-(4-chloro-2-fluorophenyl)-2-methylpropanoate

(4'-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-methoxymethoxy-3-trifluoromethyl-1-butynyl)-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)-acetic acid methyl ester

(4'-{1-ethyl-1-[3-methyl-4-((E)-4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butenyl)phenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

(4'-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-3-fluoro-2'-methyl-biphenyl-4-yl)acetic acid methyl ester

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