2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

Base Information

Chemical Name:2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid
CAS No.:1182350-53-3
Molecular Formula:C₁₇H₁₅F₃O₄
Molecular Weight:340.299
Hs Code.:

Synonyms:2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

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Chemical Property of 2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

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Technology Process of 2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

There total 4 articles about 2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1182350-52-2
2-[3-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

: 1182350-53-3
2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

Guidance literature:: 2-[3-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.25h;

With water; In methanol; ethyl acetate;

Reference yield:

: 19924-43-7
3-methoxyphenylacetonitrile

: 1182350-53-3
2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

2: potassium hydroxide; tert-butyl alcohol / 85 °C

3: hydrogen bromide; acetic acid / 100 °C

4: potassium carbonate / tetrahydrofuran / 70 °C

5: sodium tetrahydroborate / methanol / 0.25 h / 20 °C

With sodium tetrahydroborate; hydrogen bromide; sodium hexamethyldisilazane; potassium carbonate; acetic acid; potassium hydroxide; tert-butyl alcohol; In tetrahydrofuran; methanol;

Reference yield:

: 25310-30-9
2-(3-methoxyphenyl)propanenitrile

: 1182350-53-3
2-[3-(2-hydroxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide; tert-butyl alcohol / 85 °C

2: hydrogen bromide; acetic acid / 100 °C

3: potassium carbonate / tetrahydrofuran / 70 °C

4: sodium tetrahydroborate / methanol / 0.25 h / 20 °C

With sodium tetrahydroborate; hydrogen bromide; potassium carbonate; acetic acid; potassium hydroxide; tert-butyl alcohol; In tetrahydrofuran; methanol;