2-(3-methoxyphenyl)propanoic acid

Base Information

• Chemical Name: 2-(3-methoxyphenyl)propanoic acid
• CAS No.: 3146-60-9
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.203
• Mol file: 3146-60-9.mol

Synonyms:2-(3-methoxyphenyl)propanoic acid

Chemical Property of 2-(3-methoxyphenyl)propanoic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(3-methoxyphenyl)propanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-methoxyphenyl)propanoic acid

There total 21 articles about 2-(3-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(3-methoxyphenyl)propanoic acid ethyl ester (105166-35-6) → 2-(3-methoxyphenyl)propanoic acid (3146-60-9)

Guidance literature:

2-(3-methoxyphenyl)propanoic acid ethyl ester; With methanol; sodium hydroxide; water; In tetrahydrofuran; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=1;

Reference yield: 96.0%

3-methoxystyrene (626-20-0) + carbon monoxide (201230-82-2) → 2-(3-methoxyphenyl)propanoic acid (3146-60-9)

Guidance literature:

With iron(III) chloride; water; palladium diacetate; triphenylphosphine; In 1,4-dioxane; at 80 ℃; for 10h; under 37503.8 Torr; regioselective reaction; Sealed tube; Inert atmosphere; Autoclave;

DOI:10.1039/c8cc01190g

Reference yield: 92.0%

3-methoxystyrene (626-20-0) + carbon dioxide (124-38-9,18923-20-1) → 2-(3-methoxyphenyl)propanoic acid (3146-60-9)

Guidance literature:

With bis(acetylacetonate)nickel(II); diethylzinc; caesium carbonate; In tetrahydrofuran; at 23 ℃; for 12h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/ja8062925

upstream raw materials:

2-(3-methoxyphenyl)propanenitrile

diethyl (3-methoxyphenyl)methylpropanedioate

m-methoxyphenylacetic acid

methyl iodide

Downstream raw materials:

(+/-)-2-<3-Methoxy-phenyl>-propionsaeure-<2-dimethylamino-aethylester>

(+/-)-2-<3-Methoxy-phenyl>-propionsaeure-<3-dimethylamino-propylester>

methyl 2-(5-methoxy-1,4-cyclohexadienyl)propionate

2-(3-methoxy-phenyl)-propionyl chloride