N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

Base Information

Chemical Name:N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate
CAS No.:1382995-96-1
Molecular Formula:C₂HF₃O₂*C₁₈H₁₇ClN₆OS
Molecular Weight:514.916
Hs Code.:

Synonyms:N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

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Chemical Property of N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

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Technology Process of N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

There total 6 articles about N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382996-70-4
1-[5-chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethanamine

: 767-69-1
6-bromopurine

: 76-05-1
trifluoroacetic acid

: 1382995-96-1
N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

Guidance literature:: 1-[5-chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethanamine; 6-bromopurine; With N-ethyl-N,N-diisopropylamine; In ethanol; at 100 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382995-96-1
N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetic acid / 18 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: triethylamine / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Microwave; Inert atmosphere

5: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran; acetonitrile / 65 °C

6: N-ethyl-N,N-diisopropylamine / ethanol / 100 °C

With methanol; N-iodo-succinimide; ammonium acetate; sodium cyanoborohydride; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; acetone; acetonitrile;

Reference yield:

: 292144-86-6
1-(5-chloro-2-hydroxy-3-iodo-4-methylphenyl)ethan-1-one

: 1382995-96-1
N-{1-[5-Chloro-2-methoxy-4-methyl-3-(1,3-thiazol-4-yl)phenyl]ethyl}-9H-purin-6-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / Reflux

2: triethylamine / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Microwave; Inert atmosphere

4: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran; acetonitrile / 65 °C

5: N-ethyl-N,N-diisopropylamine / ethanol / 100 °C

With methanol; ammonium acetate; sodium cyanoborohydride; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; acetone; acetonitrile;