(E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Base Information

Chemical Name:(E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate
CAS No.:1356465-00-3
Molecular Formula:C₃₁H₃₅F₂N₃O₃
Molecular Weight:535.634
Hs Code.:

Synonyms:(E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

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Chemical Property of (E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

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Technology Process of (E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

There total 11 articles about (E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

: 1236144-54-9,1236148-77-8
(Z)-tert-butyl 1-(4-(N-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate

: 1356464-99-7
(E)-3-(1-(3,4-difluorophenyl)cyclohexyl)acrylic acid

: 1356465-00-3
(E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: (Z)-tert-butyl 1-(4-(N-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate; (E)-3-(1-(3,4-difluorophenyl)cyclohexyl)acrylic acid; With diisopropyl-carbodiimide; In acetonitrile; at 20 ℃; for 4.5h;

With tetrabutyl ammonium fluoride; at 20 ℃; for 9h;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1356465-00-3
(E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane; methanol / 1 h / 20 °C

1.2: 18 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / 1,2-dichloro-ethane / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 7 h / 20 °C / Reflux

4.1: diisopropyl-carbodiimide / acetonitrile / 4.5 h / 20 °C

4.2: 9 h / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropyl-carbodiimide; dmap; In methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1236144-55-0
1-(4-cyanobenzyl)azetidine-3-carboxylic acid

: 1356465-00-3
(E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / 1,2-dichloro-ethane / 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 7 h / 20 °C / Reflux

3.1: diisopropyl-carbodiimide / acetonitrile / 4.5 h / 20 °C

3.2: 9 h / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropyl-carbodiimide; dmap; In 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;