(R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

Base Information

Chemical Name:(R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal
CAS No.:252272-49-4
Molecular Formula:C₂₈H₃₅NO₅S
Molecular Weight:497.656
Hs Code.:

Synonyms:(R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

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Chemical Property of (R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

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Technology Process of (R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

There total 5 articles about (R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 169689-25-2
5-(benzyloxymethyl)-3-hydroxy-2-methylpyridine-4-carbaldehyde dimethyl acetal

: 252272-43-8
(S)-3-benzylthio-1-bromo-2-methoxypropane

: 252272-49-4
(R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

Guidance literature:: 5-(benzyloxymethyl)-3-hydroxy-2-methylpyridine-4-carbaldehyde dimethyl acetal; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(S)-3-benzylthio-1-bromo-2-methoxypropane; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1016/S0040-4020(99)00708-5

Reference yield:

: 100-53-8
phenylmethanethiol

: 252272-49-4
(R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 5 steps

1.1: MeONa / methanol / 0.17 h / 20 °C

1.2: 93 percent / benzene / 0.25 h / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 91 percent / 4 h / 20 °C

3.1: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 10 h / 20 °C

4.1: 42 percent / triphenylphosphine, NBS / CH₂Cl₂ / 0.08 h / 20 °C

5.1: NaH / dimethylformamide / 1 h / 20 °C

5.2: 64 percent / dimethylformamide / 4 h / 80 °C

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Substitution / 2.1: Metallation / 2.2: Substitution / 3.1: Substitution / 4.1: Bromination / 5.1: Metallation / 5.2: Substitution;
DOI:10.1016/S0040-4020(99)00708-5

Reference yield:

: 252272-37-0
(R)-3-benzylthio-2-methoxy-1-propanol

: 252272-49-4
(R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 42 percent / triphenylphosphine, NBS / CH₂Cl₂ / 0.08 h / 20 °C

2.1: NaH / dimethylformamide / 1 h / 20 °C

2.2: 64 percent / dimethylformamide / 4 h / 80 °C

With N-Bromosuccinimide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Bromination / 2.1: Metallation / 2.2: Substitution;
DOI:10.1016/S0040-4020(99)00708-5