169689-25-2

Upstream product

• 169689-24-1 5-(benzyloxymethyl)-3-hydroxy-2-methylpyridine-4-carbaldehyde 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 169689-32-1 5-(benzyloxymethyl)-3-(2-ethoxyethoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal 
• 252272-51-8 (S)-5-(benzyloxymethyl)-3-[2-methoxy-3-(1-naphthylmethoxy)propoxy]-2-methylpyridine-4-carbaldehyde dimethyl acetal 
• 169689-34-3 5-(benzyloxymethyl)-3-(2-ethoxyethoxy)-2-methylpyridine-4-carbaldehyde 
• 169689-33-2 5-(benzyloxymethyl)-3-methoxy-2-methylpyridine-4-carbaldehyde 
• 252272-50-7 (S)-3-(2-benzyloxy-3-methoxypropoxy)-5-(benzyloxymethyl)-2-methylpyridine-4-carbaldehyde dimethyl acetal 
• 252272-49-4 (R)-5-(benzyloxymethyl)-3-(3-benzylthio-2-methoxypropoxy)-2-methylpyridine-4-carbaldehyde dimethyl acetal 
• 252272-48-3 (S)-3-(3-benzyloxy-2-methoxypropoxy)-5-(benzyloxymethyl)-2-methylpyridine-4-carbaldehyde dimethyl acetal 
• 252272-52-9 (S)-5-(benzyloxymethyl)-3-[2-methoxy-3-(2-naphthylmethoxy)propoxy]-2-methylpyridine-4-carbaldehyde dimethyl acetal 
• 169689-31-0 5-(benzyloxymethyl)-3-methoxy-2-methylpyridine-4-carbaldehyde dimethyl acetal 

Relevant academic research and scientific papers

α-Alkylation of α-amino esters by using a pyridoxal model compound having a Li+-ionophore character

Synthesis of α,α-dialkyl-α-amino esters by α-alkylation of aldimines prepared from a novel pyridoxal model compound was studied. The α-alkylation of the aldimines having an ethoxy-ethoxy group at C-3 proceeded most rapidly when LiOH was employed as a base and gave α,α-dialkyl-α-amino esters after hydrolysis. The chelated structure composed of the aldimine and Li+ was also revealed by 1H-NMR analysis.

Efficient α-Alkylation of α-Amino Acids by Means of a Novel Pyridoxal Model Compound

α-Alkyl-α-amino esters were prepared by the alkylation of α-imino esters obtained from α-amino acids and a novel PLP model compound possessing a Li+ ionophore character.