1H-Pyrazole-5-carboxylic acid, 4,5-dihydro-, methyl ester, (S)- (9CI)

Base Information

• Chemical Name: 1H-Pyrazole-5-carboxylic acid, 4,5-dihydro-, methyl ester, (S)- (9CI)
• CAS No.: 193946-07-5
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.131
• Mol file: 193946-07-5.mol

Synonyms:1H-Pyrazole-5-carboxylicacid, 4,5-dihydro-, methyl ester, (S)- (9CI)

Chemical Property of 1H-Pyrazole-5-carboxylic acid, 4,5-dihydro-, methyl ester, (S)- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole-5-carboxylic acid, 4,5-dihydro-, methyl ester, (S)- (9CI)

There total 2 articles about 1H-Pyrazole-5-carboxylic acid, 4,5-dihydro-, methyl ester, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) + diazomethyl-trimethyl-silane (18107-18-1) → C5H8N2O2 (164928-01-2,193945-98-1,193946-07-5)

Guidance literature:

In hexanes; toluene; at 0 - 20 ℃; for 16h;

Reference yield:

magnesium methanolate (109-88-6,16436-83-2,16436-85-4) + (3,4-Dihydro-2H-pyrazol-3-yl)-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone → (S)-3,4-Dihydro-2H-pyrazole-3-carboxylic acid methyl ester (193945-98-1,193946-07-5)

Guidance literature:

DOI:10.1021/ja971708p

upstream raw materials:

magnesium methanolate

ethyl acrylate

diazomethyl-trimethyl-silane