cinnamyl bromodifluoroacetate

Base Information

• Chemical Name: cinnamyl bromodifluoroacetate
• CAS No.: 155820-77-2
• Molecular Formula: C₁₁H₉BrF₂O₂
• Molecular Weight: 291.092
• Mol file: 155820-77-2.mol

Synonyms:cinnamyl bromodifluoroacetate

Chemical Property of cinnamyl bromodifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of cinnamyl bromodifluoroacetate

There total 3 articles about cinnamyl bromodifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-Phenylpropenol (104-54-1) + difluorobromoacetyl fluoride (38126-07-7) → cinnamyl bromodifluoroacetate (155820-77-2)

Guidance literature:

With pyridine; at -20 ℃; for 0.166667h;

DOI:10.1039/P19940000725

Reference yield:

3-Phenylpropenol (104-54-1) + lithium 2-bromo-2,2-difluoroacetate → cinnamyl bromodifluoroacetate (155820-77-2)

Guidance literature:

With oxalyl dichloride; triethylamine; Yield given; Multistep reaction; 1.) Et₂O, 0 deg C, 1.5 h, 2.) Et₂O, 0 deg C, 1.5 h;

DOI:10.1021/jo982035b

Reference yield:

3-Phenylpropenol (104-54-1) + [1,1'-biphenyl]-4-yl 2-bromo-2,2-difluoroacetate → cinnamyl bromodifluoroacetate (155820-77-2)

Guidance literature:

With potassium fluoride; copper(l) iodide; potassium iodide; In N,N-dimethyl-formamide; acetonitrile; at 40 ℃; for 0.5h; Thermodynamic data; Inert atmosphere;

DOI:10.1021/acs.oprd.9b00201

upstream raw materials:

3-Phenylpropenol

difluorobromoacetyl fluoride

Downstream raw materials:

bromodifluoroacetaldehyde cinnamyl O-(trimethylsilyl)acetal

(4-Benzyl-3,3-difluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

1-phenyl-3-trifluoromethyl prop-1-ene

cinnamyl fluoride