2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

Base Information

Chemical Name:2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene
CAS No.:415949-95-0
Molecular Formula:C₂₂H₂₀F₄O₃
Molecular Weight:408.393
Hs Code.:

Synonyms:2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

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Chemical Property of 2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

Chemical Property:

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Technology Process of 2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

There total 5 articles about 2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2923-18-4
sodium 2,2,2-trifluoroacetate

: 415949-88-1
3-bromo-2-[[2-(4-fluorophenyl)ethoxy]methyl]-1,4-dimethoxynaphthalene

: 415949-95-0
2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

Guidance literature:: With copper(l) iodide; In N,N-dimethyl-formamide; toluene; at 170 ℃; for 12h;
DOI:10.1016/S0040-4020(01)00791-8

Reference yield:

: 481-85-6
2-methyl-1,4-naphthohydroquinone

: 415949-95-0
2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 5.0 g / potassium carbonate / acetone / 4 h / Heating

2: 80 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 4 h / Heating

3: 90 percent / NaH (60 percent in mineral oil) / tetrahydrofuran / 2.5 h / 40 °C

4: 85 percent / CuI / dimethylformamide; toluene / 12 h / 170 °C

With N-Bromosuccinimide; copper(l) iodide; sodium hydride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4020(01)00791-8

Reference yield:

: 58-27-5,34524-96-4
menadione

: 415949-95-0
2-[[2-(4-fluorophenyl)ethoxy]methyl]-3-trifluoromethyl-1,4-dimethoxynaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: tin(II) chloride; conc. HCl / ethanol / 1 h / 20 °C

2: 5.0 g / potassium carbonate / acetone / 4 h / Heating

3: 80 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 4 h / Heating

4: 90 percent / NaH (60 percent in mineral oil) / tetrahydrofuran / 2.5 h / 40 °C

5: 85 percent / CuI / dimethylformamide; toluene / 12 h / 170 °C

With hydrogenchloride; N-Bromosuccinimide; copper(l) iodide; sodium hydride; potassium carbonate; tin(ll) chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4020(01)00791-8