Sodium trifluoroacetate

Base Information

• Chemical Name: Sodium trifluoroacetate
• CAS No.: 2923-18-4
• Molecular Formula: C2F3NaO2
• Molecular Weight: 136.006
• Hs Code.: 29159080
• Mol file: 2923-18-4.mol

Synonyms:Aceticacid, trifluoro-, sodium salt (8CI,9CI);Sodium perfluoroacetate;Sodium trifluoromethanecarboxylate;Trifluoroacetate sodium;Trifluoroacetic acid, sodium salt;

Chemical Property of Sodium trifluoroacetate

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 96.2mmHg at 25°C
• Melting Point: 205-207 °C (dec.)(lit.)
• Boiling Point: 72.2 °C at 760 mmHg
• PSA: 40.13000
• Density: 1.49 g/mL(lit.)
• LogP: -0.70140
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility.: 625 g/L (25 ºC)

Purity/Quality:

98% ^*data from raw suppliers

Sodium trifluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Sodium trifluoroacetate is used in acid catalyzed reactions. It is also used as an intermediate for active pharmaceutical ingredients (API). Further, it acts as a precursor for the trifluoromethylation of aldehydes using copper(I) halide as a catalyst.

Technology Process of Sodium trifluoroacetate

There total 36 articles about Sodium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylsilyl trifluoroacetate (400-53-3) → sodium 2,2,2-trifluoroacetate (2923-18-4)

Guidance literature:

With sodium trimethylsilanolate; In tetrahydrofuran; at 25 ℃; for 16h;

DOI:10.1016/S0040-4039(01)81697-X

Reference yield: 66.0%

trifluoroacetic acid (76-05-1) → sodium 2,2,2-trifluoroacetate (2923-18-4)

Guidance literature:

With sodium carbonate; In water; at 20 ℃; for 0.5h;

DOI:10.1016/j.jfluchem.2019.109344

Reference yield: 52.0%

3-chloroheptafluoro-1-butene (140427-85-6) → sodium 2,2,2-trifluoroacetate (2923-18-4) + 3-chloro-1,2-epoxyheptafluorobutane (680187-38-6) + sodium; 2-chloro-2,3,3,3-tetrafluoro-propionate

Guidance literature:

With sodium hypochlorite; In acetonitrile; at 5 - 10 ℃; for 1h;

DOI:10.1023/B:RUJO.0000003178.33413.99

upstream raw materials:

2,3-dichloro-1,1,1,4,4,4-hexafluoro-2-butene

trimethylsilyl trifluoroacetate

1-bromoheptafluoro-2-butene

1-chloro-heptafluoro-2-butene

Downstream raw materials:

ethyl trifluoroacetate,

methyl-[O³-acetyl-O⁴,O⁶-((R)-benzylidene)-O²-trifluoroacetyl-α-D-glucopyranoside]

2-trifluoromethyl-4-benzylidene-Δ²-oxazolin-5-one

methyl-[O⁴,O⁶-((R)-benzylidene)-O³-trifluoroacetyl-α-D-glucopyranoside]

Refernces

• 1、 Raja Beryl,Joseph Raj. "Electrochemical trifluoromethylation of isonicotinic acid hydrazide using cyclic voltammetry and galvanostatic electrolysis". . p. 2098 - 2105. Retrieved 2018.
• 2、 Das, Manisha,Canaj, Angelos B.,Bertolasi, Valerio,Murrie, Mark,Ray, Debashis. "Strategic synthesis of [Cu2], [Cu4] and [Cu5] complexes: inhibition and triggering of ligand arm hydrolysis and self-aggregation by chosen ancillary bridges". . p. 17160 - 17176. Retrieved 2018.
• 3、 Kirihara, Masayuki,Suzuki, Katsuya,Nakakura, Kana,Saito, Katsuya,Nakamura, Riho,Tujimoto, Kazuki,Sakamoto, Yugo,Kikkawa, You,Shimazu, Hideo,Kimura, Yoshikazu. "Oxidation of fluoroalkyl alcohols using sodium hypochlorite pentahydrate [1]". . . Retrieved 2021/02/05.