{(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester

Base Information

• Chemical Name: {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester
• CAS No.: 500872-47-9
• Molecular Formula: C₃₄H₃₅BrN₂O₅
• Molecular Weight: 631.566

Synonyms:{(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester

Chemical Property of {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester

There total 8 articles about {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2-allyl-4-bromo-phenylamino)-acetic acid tert-butyl ester (500872-45-7) + (S)-N-Fmoc-C-vinylglycinyl chloride (500872-36-6) → {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester (500872-47-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/S0040-4039(02)01924-X

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester (500872-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NaHCO₃ / acetonitrile / 30 h / Heating

2: 65 percent / CH₂Cl₂ / 16 h / 20 °C

With sodium hydrogencarbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(02)01924-X

Reference yield:

N-allyl-4-bromobenzenamine (22774-76-1) → {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester (500872-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / BF₃*OEt₂ / xylene / 2 h / 180 °C

2: 73 percent / NaHCO₃ / acetonitrile / 30 h / Heating

3: 65 percent / CH₂Cl₂ / 16 h / 20 °C

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; In dichloromethane; acetonitrile; xylene; 1: aza Claisen rearrangement;

DOI:10.1016/S0040-4039(02)01924-X

upstream raw materials:

(2-allyl-4-bromo-phenylamino)-acetic acid tert-butyl ester

(S)-N-Fmoc-C-vinylglycinyl chloride

bromoacetic acid tert-butyl ester

N-allyl-4-bromobenzenamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 500872-47-9 {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send