(S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Base Information

Chemical Name:(S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine
CAS No.:1415915-01-3
Molecular Formula:C₁₁H₁₀F₄N₂O
Molecular Weight:262.207
Hs Code.:

Synonyms:(S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Technology Process of (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

There total 10 articles about (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 289-82-7
2H-1,2-oxazine

: 1415915-00-2
(S)-3-amino-2,2,4-trifluoro-3-(2-fluoro-phenyl)-butan-1-ol

: 506-68-3
bromocyane

: 1415915-01-3
(S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:

Reference yield: 41.0%

: 1415915-01-3
(S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:

Reference yield:

: 1415914-97-4
(R)-2-methyl-propane-2-sulfinic acid [2-fluoro-1-(2-fluoro-phenyl)-eth-(E)-ylidene]-amide

: 1415915-01-3
(S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

1.2: -20 °C / Inert atmosphere

2.1: lithium borohydride / ethanol / 22 °C

3.1: hydrogenchloride / tetrahydrofuran; water / 22 °C

4.1: ethanol / 80 - 95 °C / Sealed tube

With hydrogenchloride; lithium borohydride; copper(l) chloride; zinc; In tetrahydrofuran; ethanol; water; 1.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m