Technology Process of (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate
There total 2 articles about (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 50 - 70 °C / Inert atmosphere
2.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere
2.2: -20 °C / Inert atmosphere
With
titanium(IV) tetraethanolate; copper(l) chloride; zinc;
In
tetrahydrofuran;
2.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / dichloromethane / 0 - 22 °C / Sealed tube
2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 50 - 70 °C / Inert atmosphere
3.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere
3.2: -20 °C / Inert atmosphere
With
titanium(IV) tetraethanolate; Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine; copper(l) chloride; zinc;
In
tetrahydrofuran; dichloromethane;
3.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran;
for 0.5h;