(E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Base Information

Chemical Name:(E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide
CAS No.:1374855-94-3
Molecular Formula:C₂₅H₂₇ClN₄O₃
Molecular Weight:466.967
Hs Code.:

Synonyms:(E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

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Chemical Property of (E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Chemical Property:

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Technology Process of (E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

There total 12 articles about (E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24393-52-0
ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

: 1374855-94-3
(E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 16 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 0 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 1374856-47-9
C₁₆H₂₂N₄O₂

: 1374855-94-3
(E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

: 551-93-9
2-aminoacetophenone

: 1374855-94-3
(E)-3-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1: dmap / tetrahydrofuran / 2 h / 0 - 35 °C

2: ammonium acetate / dimethyl sulfoxide / 24 h / 20 - 35 °C

3: sulfuric acid; silver nitrate / 2.5 h / 0 °C

4: trichlorophosphate / 2 h / 0 °C / Reflux

5: triethylamine / methanol / 2 h / Reflux

6: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 0 - 20 °C

With dmap; sulfuric acid; palladium 10% on activated carbon; ammonium acetate; hydrogen; benzotriazol-1-ol; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.03.049