C₂₁H₂₃FN₄O₃S

Base Information

Chemical Name:C₂₁H₂₃FN₄O₃S
CAS No.:1374229-80-7
Molecular Formula:C₂₁H₂₃FN₄O₃S
Molecular Weight:430.503
Hs Code.:

C<sub>21</sub>H<sub>23</sub>FN<sub>4</sub>O<sub>3</sub>S

Synonyms:C₂₁H₂₃FN₄O₃S

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Chemical Property of C₂₁H₂₃FN₄O₃S

Chemical Property:

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Technology Process of C₂₁H₂₃FN₄O₃S

There total 12 articles about C₂₁H₂₃FN₄O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31872-62-5
4-methoxy-3-nitro-pyridine

: 1374229-79-4
C₂₁H₂₃FN₄O₃S

: 1374229-80-7
C₂₁H₂₃FN₄O₃S

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C

2.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

3.1: dichloromethane / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

6.1: 2-(diethylamino)ethanethiol hydrochloride; sodium t-butanolate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Reflux

6.2: 0 °C / pH 3 - 4

7.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0.5 h / 0 °C

8.1: sodium acetate / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

9.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 16 h / 20 °C

10.1: lithium hydroxide / tetrahydrofuran; methanol / 48 h / 75 °C

10.2: 20 °C / pH 5 - 6

11.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

11.2: 0.5 h / 20 °C

12.1: Daicel CHIRALPAK IA / ethanol; hexane; diethylamine / Resolution of racemate

With 2-(diethylamino)ethanethiol hydrochloride; hydrogen; sodium acetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; sodium t-butanolate; dmap; (diphenylphosphin)ferrocene; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; diethylamine; N,N-dimethyl-formamide;

Reference yield:

: 33631-09-3
4-methoxypyridin-3-amine

: 1374229-79-4
C₂₁H₂₃FN₄O₃S

: 1374229-80-7
C₂₁H₂₃FN₄O₃S

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

2.1: dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

5.1: 2-(diethylamino)ethanethiol hydrochloride; sodium t-butanolate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Reflux

5.2: 0 °C / pH 3 - 4

6.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0.5 h / 0 °C

7.1: sodium acetate / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 16 h / 20 °C

9.1: lithium hydroxide / tetrahydrofuran; methanol / 48 h / 75 °C

9.2: 20 °C / pH 5 - 6

10.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

10.2: 0.5 h / 20 °C

11.1: Daicel CHIRALPAK IA / ethanol; hexane; diethylamine / Resolution of racemate

With 2-(diethylamino)ethanethiol hydrochloride; hydrogen; sodium acetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; sodium t-butanolate; dmap; (diphenylphosphin)ferrocene; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; diethylamine; N,N-dimethyl-formamide;

Reference yield:

: 1374233-59-6
N-(4-methoxypyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide

: 1374229-79-4
C₂₁H₂₃FN₄O₃S

: 1374229-80-7
C₂₁H₂₃FN₄O₃S

Guidance literature:: Multi-step reaction with 10 steps

1.1: dichloromethane / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: 2-(diethylamino)ethanethiol hydrochloride; sodium t-butanolate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Reflux

4.2: 0 °C / pH 3 - 4

5.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0.5 h / 0 °C

6.1: sodium acetate / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 16 h / 20 °C

8.1: lithium hydroxide / tetrahydrofuran; methanol / 48 h / 75 °C

8.2: 20 °C / pH 5 - 6

9.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

9.2: 0.5 h / 20 °C

10.1: Daicel CHIRALPAK IA / ethanol; hexane; diethylamine / Resolution of racemate

With 2-(diethylamino)ethanethiol hydrochloride; hydrogen; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; sodium t-butanolate; dmap; (diphenylphosphin)ferrocene; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; diethylamine; N,N-dimethyl-formamide;