2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

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Chemical Name:2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide
CAS No.:1257387-53-3
Molecular Formula:C₃₆H₃₇F₂N₅O₄
Molecular Weight:641.718
Hs Code.:

2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

Synonyms:2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

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Chemical Property of 2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

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Technology Process of 2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

There total 6 articles about 2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 957130-49-3
(R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one

: 1257388-01-4
tert-butyl 4-carboxymethyl-(3R)-(3,5-difluorophenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]-hexadecane-1-carboxylate

: 1257387-53-3
2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

Guidance literature:: (R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one; tert-butyl 4-carboxymethyl-(3R)-(3,5-difluorophenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]-hexadecane-1-carboxylate; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; In methanol; at 50 ℃; for 1h;

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1257387-53-3
2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / toluene / 6 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 50 °C / 2250.23 Torr / Inert atmosphere

3.1: N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide / dichloromethane / Cooling with acetone-dry ice

3.2: 0 - 20 °C

3.3: 0 °C / pH 1

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

5.2: 5.5 h / 0 - 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

6.2: pH 7

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

7.2: 1 h / 50 °C

With sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1159280-52-0
9-oxaspiro[5.5]undec-4-en-3-one

: 1257387-53-3
2-((R)-3-(3,5-difluoro-phenyl)-5-oxo-12-oxa-1,4-diaza-dispiro[5.2.5.2]hexadecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 50 °C / 2250.23 Torr / Inert atmosphere

2.1: N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide / dichloromethane / Cooling with acetone-dry ice

2.2: 0 - 20 °C

2.3: 0 °C / pH 1

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

4.2: 5.5 h / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

5.2: pH 7

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

6.2: 1 h / 50 °C

With N-benzyl-N,N,N-triethylammonium chloride; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;