(R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Base Information

Chemical Name:(R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.:957130-49-3
Molecular Formula:C15H13N3O
Molecular Weight:251.288
Hs Code.:2933990090
DSSTox Substance ID:DTXSID70693241
Wikidata:Q82622277
Mol file:957130-49-3.mol

Synonyms:957130-49-3;(R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one;(2R)-5-aminospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-2'-one;(2R)-5-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one;SCHEMBL549390;DTXSID70693241;BWGAKJLOJFNCFI-OAHLLOKOSA-N;W15020;(R)-5-amino-1,3-dihydro spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one;(R)-5-amino-1,3-dihydro-spiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one;(R)-5-amino-1,3-dihydrospiro[inden-2,3'-pyrrol[2,3-b]pyridin]-2'(1'H)-one;(R)-5-amino-1,3-dihydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Suppliers and Price of (R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(R)-5-amino-1,3-dihydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridin]-2''(1''H)-one 95%
250mg
$ 598.00

American Custom Chemicals Corporation
(R)-5-AMINO-1,3-DIHYDROSPIRO[INDENE-2,3'-PYRROLO[2,3-B]PYRIDIN]-2'(1'H)-ONE 95.00%
1G
$ 2264.85

American Custom Chemicals Corporation
(R)-5-AMINO-1,3-DIHYDROSPIRO[INDENE-2,3'-PYRROLO[2,3-B]PYRIDIN]-2'(1'H)-ONE 95.00%
5MG
$ 504.87

Total 6 raw suppliers

Chemical Property of (R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Chemical Property:

Boiling Point:512.0±50.0 °C(Predicted)
PKA:11.91±0.20(Predicted)
PSA：71.50000
Density:1.40±0.1 g/cm3(Predicted)
LogP:2.31880
Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:251.105862047
Heavy Atom Count:19
Complexity:399

Purity/Quality:

99.3% ^*data from raw suppliers

(R)-5-amino-1,3-dihydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridin]-2''(1''H)-one 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)N
Isomeric SMILES:C1C2=C(C[C@@]13C4=C(NC3=O)N=CC=C4)C=C(C=C2)N

Technology Process of (R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

There total 35 articles about (R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1260403-57-3
(R)-1’-(tert-butyl)-5-(dibenzylamino)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one

: 957130-49-3
(R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one

Guidance literature:: (R)-1’-(tert-butyl)-5-(dibenzylamino)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one; With methanesulfonic acid; In methanol; for 4h; Reflux;

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;
DOI:10.1021/acs.jmedchem.0c02191

Reference yield:

: (x)CH₄O₃S*C₂₉H₂₅N₃O

: 957130-49-3
(R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one

Guidance literature:: (x)CH₄O₃S*C₂₉H₂₅N₃O; With hydrogen; palladium 10% on activated carbon; In methanol; toluene; at 20 - 27 ℃; under 3102.97 Torr; Industry scale;

With sodium hydroxide; In methanol; water; toluene; at 20 ℃; pH=6.3; Industry scale;