Technology Process of 3S-(2-(N-isobutyrylguanin-9-yl))-5S-(hydroxymethyl)-N-benzyl-2-pyrrolidinone
There total 20 articles about 3S-(2-(N-isobutyrylguanin-9-yl))-5S-(hydroxymethyl)-N-benzyl-2-pyrrolidinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
methanol; water;
for 48h;
DOI:10.1021/jo2004617
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / toluene / Reflux
2: lithium hexamethyldisilazane / tetrahydrofuran
3: di-isopropyl azodicarboxylate; acetic acid; triphenylphosphine / tetrahydrofuran
4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C
5: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 0 - 20 °C
6: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 48 h
With
pyridine; hydrogenchloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water; toluene;
3: Mitsunobu reaction / 4: Mitsunobu reaction;
DOI:10.1021/jo2004617
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / toluene / 60 h / Reflux; Dean-Stark
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h
3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C
4: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 0 - 20 °C
5: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 48 h
With
pyridine; hydrogenchloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine;
In
tetrahydrofuran; methanol; water; toluene;
3: Mitsunobu reaction;
DOI:10.1021/jo2004617
