(2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

Base Information

Chemical Name:(2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate
CAS No.:945493-38-9
Molecular Formula:C₂₄H₄₀N₂O₇SSi
Molecular Weight:528.742
Hs Code.:

Synonyms:(2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

Chemical Property:

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Technology Process of (2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

There total 9 articles about (2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 945493-37-8
methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

: 106-95-6
allyl bromide

: 945493-38-9
(2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1039/b702649h

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 945493-38-9
(2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: H₂SO₄

1.2: pyridine / ethanol

2.1: triethylamine / dimethylformamide

3.1: potassium carbonate / dimethylformamide

4.1: 42 g / H₂ / Pd/C / ethanol

5.1: triethylamine

6.1: NaBH₄ / methanol; tetrahydrofuran

7.1: triethylamine / dimethylformamide / 5 h / 20 °C

7.2: TFA / CH₂Cl₂ / 1 h / 0 °C

8.1: 4.95 g / triethylamine / CH₂Cl₂

9.1: 82 percent / potassium carbonate / dimethylformamide / 3 h / 20 °C

With sodium tetrahydroborate; sulfuric acid; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b702649h

Reference yield:

: 59279-58-2
N^α-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester

: 945493-38-9
(2S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-N-allylamino]-5-(triisopropylsilyloxy)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 42 g / H₂ / Pd/C / ethanol

2.1: triethylamine

3.1: NaBH₄ / methanol; tetrahydrofuran

4.1: triethylamine / dimethylformamide / 5 h / 20 °C

4.2: TFA / CH₂Cl₂ / 1 h / 0 °C

5.1: 4.95 g / triethylamine / CH₂Cl₂

6.1: 82 percent / potassium carbonate / dimethylformamide / 3 h / 20 °C

With sodium tetrahydroborate; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b702649h