(R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Base Information

Chemical Name:(R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane
CAS No.:760978-02-7
Molecular Formula:C₁₉H₃₀O₃
Molecular Weight:306.445
Hs Code.:

Synonyms:(R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

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Technology Process of (R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

There total 4 articles about (R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 760977-96-6
Toluene-4-sulfonic acid (2R,3R,4S)-3-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxan-4-yl)-2-methyl-pentyl ester

: 760978-02-7
(R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;
DOI:10.1016/j.tetlet.2004.06.121

Reference yield:

: 96691-92-8
(1R,2R,3r,4S,5S)-3-(benzyloxy)-2,4-dimethyl-8-oxa-bicyclo[3.2.1]oct-6-ene

: 760978-02-7
(R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 7 steps

1.1: (-)-diisopinocampheylborane / tetrahydrofuran / 24 h / -23 °C

1.2: 95 percent / aq. NaOH; aq. H₂O₂ / 6 h / 20 °C

2.1: 94 percent / PCC / CH₂Cl₂ / 20 °C

3.1: 88 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 10 h / 20 °C

4.1: 85 percent / LAH / tetrahydrofuran / 4 h / 0 - 20 °C

5.1: 73 percent / CSA / acetone / 3 h

6.1: 95 percent / NEt₃; DMAP / CH₂Cl₂

7.1: 92 percent / LAH / tetrahydrofuran / 3 h / Heating

With dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; diisopinocampheylborane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone; 3.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.06.121

Reference yield:

: 238757-51-2
(1S,5R,6S,7S,8S)-7-Benzyloxy-6,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-3-one

: 760978-02-7
(R)-4-((1S,2R)-2-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / LAH / tetrahydrofuran / 4 h / 0 - 20 °C

2: 73 percent / CSA / acetone / 3 h

3: 95 percent / NEt₃; DMAP / CH₂Cl₂

4: 92 percent / LAH / tetrahydrofuran / 3 h / Heating

With dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2004.06.121