4-(4-Fluorobenzyl)piperidine hydrochloride

Base Information

• Chemical Name: 4-(4-Fluorobenzyl)piperidine hydrochloride
• CAS No.: 193357-52-7
• Molecular Formula: BrH*C₁₂H₁₆FN
• Molecular Weight: 274.176
• Hs Code.: 2933399090
• European Community (EC) Number: 872-568-5,948-352-2
• ChEMBL ID: CHEMBL1204355
• DSSTox Substance ID: DTXSID30588780
• Mol file: 193357-52-7.mol

Synonyms:4-(4-Fluorobenzyl)piperidine hydrochloride;92822-03-2;193357-52-7;Piperidine, 4-[(4-fluorophenyl)methyl]-, hydrochloride;C12H17ClFN;4-[(4-fluorophenyl)methyl]piperidine Hydrochloride;4-(4-Fluoro-benzyl)-piperidine hydrochloride;4-[(4-fluorophenyl)methyl]piperidine;hydrochloride;4-(4-FLUOROBENZYL)PIPERIDINE HCL;CHEMBL1204355;MFCD03840140;4-(4'-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE;4-(4-Fluorobenzyl)piperidineHydrochloride;SCHEMBL4247331;DTXSID30588780;OJKWWANXBGLGQN-UHFFFAOYSA-N;AR1826;AKOS015891419;AB16392;DL-0726;PD181765;SY046053;4-(4-fluorobenzyl)-piperidine hydrochloride;DB-014359;DB-106003;4-(4-fluorophenylmethyl)piperidine HCl salt;CS-0045397;EN300-1215324;4-(4-Fluorobenzyl)piperidine hydrochloride (1:1);A849538;A911468;A1-50279;4-(4-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE Salt;4-(4-Fluorobenzyl)piperidine hydrochloride, AldrichCPR;F9995-3600;4-[(4-Fluorophenyl)methyl]piperidine--hydrogen chloride (1/1);4-(4-Fluoro-benzyl)-piperidine;4-(4-Fluorobenzyl)piperidine Hydrochloride

Chemical Property of 4-(4-Fluorobenzyl)piperidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000245mmHg at 25°C
• Boiling Point: 319.6°C at 760 mmHg
• Flash Point: 147.1°C
• PSA: 12.03000
• LogP: 3.49860
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 229.1033554
• Heavy Atom Count: 15
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Fluorobenzyl)piperidineHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1CC2=CC=C(C=C2)F.Cl
• Uses: Reactant in the synthesis of 4-(Substituted-benzyl)piperidines and (±)-3-(Substituted-benzyl)pyrrolidines. It an important and valuable pharmaceutical intermediate.

Technology Process of 4-(4-Fluorobenzyl)piperidine hydrochloride

There total 2 articles about 4-(4-Fluorobenzyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

triethylsilane (617-86-7) + 4-(4-fluorobenzoyl)piperidine hydrobromide (142221-79-2) → 4-(4-fluorobenzyl)piperidine hydrobromide (193357-52-7)

Guidance literature:

With hydrogen bromide; In methanol; trifluoroacetic acid;

Reference yield:

1-(4-(4-fluorobenzoyl)piperidin-1-yl)ethanone (25519-77-1) → 4-(4-fluorobenzyl)piperidine hydrobromide (193357-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; methanol; hydrogen bromide

2: hydrogen bromide / methanol; trifluoroacetic acid

With hydrogen bromide; In hydrogenchloride; methanol; hydrogen bromide; trifluoroacetic acid;

upstream raw materials:

triethylsilane

4-(4-fluorobenzoyl)piperidine hydrobromide

1-(4-(4-fluorobenzoyl)piperidin-1-yl)ethanone