ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

Base Information

Chemical Name:ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate
CAS No.:1612886-91-5
Molecular Formula:C₁₆H₁₂F₂N₄O₂S
Molecular Weight:362.36
Hs Code.:

Synonyms:ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

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Chemical Property of ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

Chemical Property:

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Technology Process of ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

There total 4 articles about ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1612887-05-4
ethyl 2-(2-aminopyrimidin-4-yl)-4-(trifluoromethylsulfonyloxy)thiazole-5-carboxylate

: 193353-34-3
2,5-difurorboronic acid

: 1612886-91-5
ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

Guidance literature:: With trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate monohydrate; In 1,4-dioxane; water; at 60 ℃; for 1.5h;
DOI:10.1016/j.ejmech.2014.04.013

Reference yield:

: 36314-98-4
2-aminopyrimidine-4-carbonitrile

: 1612886-91-5
ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: diammonium sulfide; triethylamine; pyridine / 2 h / 52 °C

2: pyridine / ethanol / 16 h / Reflux

3: pyridine / dichloromethane / 2 h / 0 °C

4: trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate monohydrate / water; 1,4-dioxane / 1.5 h / 60 °C

With pyridine; diammonium sulfide; trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate monohydrate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; 4: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.04.013

Reference yield:

: 1612886-82-4
ethyl 2-(2-aminopyrimidin-4-yl)-4-hydroxythiazole-5-carboxylate

: 1612886-91-5
ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2 h / 0 °C

2: trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate monohydrate / water; 1,4-dioxane / 1.5 h / 60 °C

With pyridine; trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate monohydrate; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.04.013