36314-98-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyrimidinecarbonitrile, 2-amino(9CI) is used as an intermediate compound for the synthesis of various pharmaceutical products. Its unique chemical structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
In the field of chemical research, 4-Pyrimidinecarbonitrile, 2-amino(9CI) serves as a valuable compound for studying the properties and reactivity of pyrimidine derivatives. This can lead to a better understanding of their potential applications and the development of new compounds with improved properties.
Used in Agrochemical Industry:
4-Pyrimidinecarbonitrile, 2-amino(9CI) may also find applications in the agrochemical industry, where it can be used as a building block for the development of new pesticides or other agrochemical products. Its unique structure could potentially contribute to the creation of more effective and targeted products for agricultural use.

Upstream product

• 557-21-1 zinc(II) cyanide 
• 815610-16-3 4-iodo-2-aminopyrimidine 
• 3993-78-0 2-amino-4-chloropyrimidine 
• 64376-15-4 2-aminopyrimidine-4,6-dicarbonitrile 

Downstream Products

• 1612886-89-1 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-fluorophenyl)thiazole-5-carboxylate 
• 1612886-90-4 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-trifluoromethylphenyl)thiazole-5-carboxylate 
• 1612886-91-5 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate 
• 1612886-93-7 ethyl 2-(2-aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)thiazole-5-carboxylate 
• 1612886-94-8 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-chloro-4-methylphenyl)thiazole-5-carboxylate 
• 1612886-95-9 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-chloro-4-methoxyphenyl)thiazole-5-carboxylate 
• 1612887-10-1 2-(2-aminopyrimidin-4-yl)-4-(2-fluorophenyl)thiazole-5-carboxylic acid 
• 1612886-97-1 2-(2-aminopyrimidin-4-yl)-4-(2-fluorophenyl)thiazole-5-carboxamide 
• 1612887-11-2 2-(2-aminopyrimidin-4-yl)-4-(2-trifluoromethylphenyl)thiazole-5-carboxylic acid 
• 1612886-98-2 2-(2-aminopyrimidin-4-yl)-4-(2-trifluoromethylphenyl)thiazole-5-carboxamide 
• 1612887-12-3 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylic acid 
• 1612886-99-3 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxamide 
• 1612887-13-4 2-(2-aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)thiazole-5-carboxylic acid 
• 1612887-01-0 2-(2-aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)thiazole-5-carboxamide 

Relevant academic research and scientific papers

Efficient synthesis of pyrimidinecarbonitriles and their derivatives

New approach to pyrimidinecarbonitriles was developed. Pyrimidine-4- and 6-carbonitriles were prepared by palladium-catalyzed cross-coupling reaction of iodopyrimidines with Zn(CN)2 in very good yields. The cyano group was converted into the co

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, metho