36314-98-4

Basic information

• Product Name: 4-Pyrimidinecarbonitrile, 2-amino- (9CI)
• Synonyms: 4-Pyrimidinecarbonitrile, 2-amino- (9CI);2-aminopyrimidine-4-carbonitrile;2-Amino-4-pyrimidinecarbonitrile;4-Pyrimidinecarbonitrile,2-amino-
• CAS NO: 36314-98-4
• Molecular Formula: C5H4N4
• Molecular Weight: 120.11206
• EINECS: 200-001-2
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 36314-98-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 222 °C (decomp)
• Boiling Point: 387.9±34.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.63±0.10(Predicted)
• CAS DataBase Reference: 4-Pyrimidinecarbonitrile, 2-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinecarbonitrile, 2-amino- (9CI)(36314-98-4)
• EPA Substance Registry System: 4-Pyrimidinecarbonitrile, 2-amino- (9CI)(36314-98-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 36314-98-4(Hazardous Substances Data)

Usage

Uses

2-Amino-4-pyrimidinecarbonitrile is a derivative of Pyrimidine (P997330), a heterocyclic organic molecule present in many pharmaceutical and naturally derived compounds.

Upstream product

• 64376-15-4 2-aminopyrimidine-4,6-dicarbonitrile 
• 557-21-1 zinc(II) cyanide 
• 815610-16-3 4-iodo-2-aminopyrimidine 
• 3993-78-0 2-amino-4-chloropyrimidine 

Downstream Products

• 1612886-89-1 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-fluorophenyl)thiazole-5-carboxylate 
• 1612886-90-4 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-trifluoromethylphenyl)thiazole-5-carboxylate 
• 1612886-91-5 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylate 
• 1612886-93-7 ethyl 2-(2-aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)thiazole-5-carboxylate 
• 1612886-94-8 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-chloro-4-methylphenyl)thiazole-5-carboxylate 
• 1612886-95-9 ethyl 2-(2-aminopyrimidin-4-yl)-4-(2-chloro-4-methoxyphenyl)thiazole-5-carboxylate 
• 1612887-10-1 2-(2-aminopyrimidin-4-yl)-4-(2-fluorophenyl)thiazole-5-carboxylic acid 
• 1612886-97-1 2-(2-aminopyrimidin-4-yl)-4-(2-fluorophenyl)thiazole-5-carboxamide 
• 1612887-11-2 2-(2-aminopyrimidin-4-yl)-4-(2-trifluoromethylphenyl)thiazole-5-carboxylic acid 
• 1612886-98-2 2-(2-aminopyrimidin-4-yl)-4-(2-trifluoromethylphenyl)thiazole-5-carboxamide 
• 1612887-12-3 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxylic acid 
• 1612886-99-3 2-(2-aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)thiazole-5-carboxamide 
• 1612887-13-4 2-(2-aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)thiazole-5-carboxylic acid 
• 1612887-01-0 2-(2-aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)thiazole-5-carboxamide 

Relevant articles and documents

Efficient synthesis of pyrimidinecarbonitriles and their derivatives

New approach to pyrimidinecarbonitriles was developed. Pyrimidine-4- and 6-carbonitriles were prepared by palladium-catalyzed cross-coupling reaction of iodopyrimidines with Zn(CN)2 in very good yields. The cyano group was converted into the co

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, metho