5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine

Base Information

• Chemical Name: 5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine
• CAS No.: 1186482-52-9
• Molecular Formula: C₁₇H₁₀ClF₂N₅
• Molecular Weight: 357.75

Synonyms:5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine

Chemical Property of 5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine

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Technology Process of 5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine

There total 1 articles about 5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + 2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine (1105058-57-8) → 5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine (1186482-52-9)

Guidance literature:

Reference yield:

(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid (1186482-51-8) + 5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine (1186482-52-9) → 2-(2,3-Difluoro-phenyl)-5-[6-(4-propoxy-2-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-5H-imidazo[4,5-d]pyridazine (1186484-54-7)

Guidance literature:

With potassium phosphate; Pd(PPh₃)4; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine (1186482-52-9) + (4-methoxy-2-(trifluoromethyl)phenyl)boronic acid (313546-16-6) → 2-(2,3-Difluoro-phenyl)-5-[6-(4-methoxy-2-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-5H-imidazo[4,5-d]pyridazine (1186483-51-1)

Guidance literature:

upstream raw materials:

2-chloro-5-(chloromethyl)pyridine

2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

Downstream raw materials:

2-(2,3-Difluoro-phenyl)-5-[6-(4-propoxy-phenyl)-pyridin-3-ylmethyl]-5H-imidazo[4,5-d]pyridazine

2-(2,3-Difluoro-phenyl)-5-[6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethyl]-5H-imidazo[4,5-d]pyridazine

2-(2,3-Difluoro-phenyl)-5-[6-(4-methoxy-2-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-5H-imidazo[4,5-d]pyridazine

5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

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