5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

Base Information

Chemical Name:5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine
CAS No.:1186483-13-5
Molecular Formula:C₂₅H₁₃F₈N₅
Molecular Weight:535.399
Hs Code.:

Synonyms:5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

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Chemical Property of 5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

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Technology Process of 5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

There total 11 articles about 5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153254-09-2
2,4-bis(trifluoromethyl)phenylboronic acid

: 1186482-52-9
5-(6-chloro-pyridin-3-ylmethyl)-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine

: 1186483-13-5
5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

Guidance literature:

Reference yield:

: 327-75-3
1-bromo-2,4-di(trifluoromethyl)benzene

: 1186483-13-5
5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.17 h / 130 °C / Microwave irradiation

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 45 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401337x

Reference yield:

: 257876-05-4
(5-methylpyridin-2-yl)zinc(II) bromide

: 1186483-13-5
5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.17 h / 130 °C / Microwave irradiation

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 45 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401337x