(Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

Base Information

Chemical Name:(Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane
CAS No.:299957-31-6
Molecular Formula:C₁₉H₁₅NO₃
Molecular Weight:305.333
Hs Code.:

Synonyms:(Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

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Technology Process of (Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

There total 2 articles about (Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 299957-27-0
2-Phenyl-6-[1-phenyl-meth-(Z)-ylidene]-1-oxa-5-aza-spiro[2.4]heptane-4,7-dione

: 74-88-4
methyl iodide

: 299957-31-6
(Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

Guidance literature:: 2-Phenyl-6-[1-phenyl-meth-(Z)-ylidene]-1-oxa-5-aza-spiro[2.4]heptane-4,7-dione; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; for 1h;
DOI:10.1002/1521-4184(20007)333:7<211::AID-ARDP211>3.0.CO;2-9

Reference yield:

: 108045-40-5
3,5-Bis-benzyliden-pyrrolidin-2,4-dion

: 299957-31-6
(Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / H₂O₂; aq. NaOH / methanol / 0.5 h

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 65 percent / dimethylformamide / 1 h

With sodium hydroxide; dihydrogen peroxide; sodium hydride; In methanol; N,N-dimethyl-formamide; 1.1: Epoxidation / 2.1: deprotonation / 2.2: Methylation;
DOI:10.1002/1521-4184(20007)333:7<211::AID-ARDP211>3.0.CO;2-9

Reference yield: 35.0%

: 299957-31-6
(Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane

: 299957-21-4
3-Hydroxy-1-methyl-4-phenyl-6-[1-phenyl-meth-(Z)-ylidene]-1,6-dihydro-pyridine-2,5-dione

Guidance literature:: With triethyloxonium fluoroborate; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/1521-4184(20007)333:7<211::AID-ARDP211>3.0.CO;2-9