4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

Base Information

• Chemical Name: 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide
• CAS No.: 59180-30-2
• Molecular Formula: C₂₆H₂₅Cl₂N₃O₅
• Molecular Weight: 530.408
• Mol file: 59180-30-2.mol

Synonyms:4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

Chemical Property of 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

There total 2 articles about 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CbzGlyGly (2566-19-0) + 2-methylamino-5,2'-dichlorobenzhydrol (59180-29-9) → 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (59180-30-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; Yield given. Multistep reaction; 1.) CH₃CN, -18 deg C, 30 min, 2.) CH₃CN, -20 deg C, overnight;

DOI:10.1021/jm00181a013

Reference yield:

2',5-dichloro-2-methylaminobenzophenone (5621-86-3) → 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (59180-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97.1 percent / NaBH₄ / tetrahydrofuran; H₂O / Ambient temperature

2: 1.) HMPA, SOCl₂ / 1.) CH₃CN, -18 deg C, 30 min, 2.) CH₃CN, -20 deg C, overnight

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; water;

DOI:10.1021/jm00181a013

Reference yield: 98.5%

4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (59180-30-2) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (59179-98-5)

Guidance literature:

With jones reagent; In acetone;

DOI:10.1021/jm00181a013

upstream raw materials:

CbzGlyGly

2-methylamino-5,2'-dichlorobenzhydrol

2',5-dichloro-2-methylaminobenzophenone

Downstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide