Benzophenone, 2',5-dichloro-2-methylamino-

Base Information

• Chemical Name: Benzophenone, 2',5-dichloro-2-methylamino-
• CAS No.: 5621-86-3
• Molecular Formula: C14H11 Cl2 N O
• Molecular Weight: 280.153
• European Community (EC) Number: 227-050-8
• UNII: WUH83J8VCG
• DSSTox Substance ID: DTXSID00204748
• Nikkaji Number: J225.058F
• Wikidata: Q63392700
• Mol file: 5621-86-3.mol

Synonyms:5621-86-3;2',5-Dichloro-2-(methylamino)benzophenone;BENZOPHENONE, 2',5-DICHLORO-2-METHYLAMINO-;2-Methylamino-2',5-dichlorobenzophenone;(5-Chloro-2-(methylamino)phenyl)(2-chlorophenyl)methanone;[5-chloro-2-(methylamino)phenyl]-(2-chlorophenyl)methanone;EINECS 227-050-8;BRN 0793664;2'-Chloro-2-methylamino-5-chlorobenzophenone;Methanone, [5-chloro-2-(methylamino)phenyl](2-chlorophenyl)-;WUH83J8VCG;Methanone, (5-chloro-2-(methylamino)phenyl)(2-chlorophenyl)-;C14H11Cl2NO;[5-Chloro-2-(methylamino)phenyl](2-chlorophenyl)methanone;UNII-WUH83J8VCG;SCHEMBL9726995;DTXSID00204748;MFCD01662307;AKOS028108405;SB82404;2',5-dichloro-2-methylaminobenzophenone;2-methylamino-2',5-dichlor-benzophenone;2-Methylamino-5,2'-dichlorobenzophenone;2', 5-dichloro-2-methylaminobenzophenone;2-methylamino-2', 5-dichlorobenzophenone;AS-65044;LS-38897;2-methylamino-2' ,5-dichlor-benzophenone;CS-0047335;4-CHLORO-2-(2-CHLOROBENZOYL)-N-METHYLANILINE;Q63392700;[5-Chloro-2-(methylamino)phenyl](2-chlorophenyl) ketone;[5-Chloro-2-(methylamino)phenyl](2-chlorophenyl)-methanone;[5-Chloro-2-(methylamino)phenyl](2-chlorophenyl)methanone #

Chemical Property of Benzophenone, 2',5-dichloro-2-methylamino-

Chemical Property:

• Boiling Point: 450.8°Cat760mmHg
• Flash Point: 226.4°C
• PSA: 29.10000
• Density: 1.328g/cm³
• LogP: 4.33910
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 279.0217694
• Heavy Atom Count: 18
• Complexity: 298

Purity/Quality:

99% ^*data from raw suppliers

(5-Chloro-2-(methylamino)phenyl)(2-chlorophenyl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=C(C=C(C=C1)Cl)C(=O)C2=CC=CC=C2Cl

Technology Process of Benzophenone, 2',5-dichloro-2-methylamino-

There total 7 articles about Benzophenone, 2',5-dichloro-2-methylamino- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimethyl sulfate (77-78-1) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 2',5-dichloro-2-methylaminobenzophenone (5621-86-3)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; at 60 ℃; for 1h;

DOI:10.1055/s-1981-29477

Reference yield: 91.0%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) + methyl iodide (74-88-4) → 2',5-dichloro-2-methylaminobenzophenone (5621-86-3)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield: 63.0%

trimethylsilyl iodide (16029-98-4) + C14H10Cl2NO(1+)*CH3O4S(1-) (94341-58-9) → 2',5-dichloro-2-methylaminobenzophenone (5621-86-3)

Guidance literature:

In chloroform; for 10h; Ambient temperature;

upstream raw materials:

trimethylsilyl iodide

C₁₄H₁₀Cl₂NO⁽¹⁺⁾*CH₃O₄S^(1-)

dimethyl sulfate

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

Downstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

((S)-1-{[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-ethyl)-carbamic acid benzyl ester

2-methylamino-5,2'-dichlorobenzhydrol

2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-methyl-butyramide