(2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate
CAS No.:1337862-74-4
Molecular Formula:C₂₁H₃₉NO₄Si
Molecular Weight:397.63
Hs Code.:

Synonyms:(2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

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Chemical Property of (2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

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Technology Process of (2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

There total 4 articles about (2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1337862-67-5
tert-butyl (1S,2R)-2-(tert-butyldimethylsilyloxy)-1-cyclohexylpent-4-enylcarbamate

: 1337862-74-4
(2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2011.07.049

Reference yield:

: 864801-48-9
tert-butyl (S)-(1-cyclohexyl-2-(methoxy(methyl)amino)-2-oxoethyl)carbamate

: 1337862-74-4
(2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

2: lithium tri-t-butoxyaluminum hydride / ethanol / 2 h / -78 °C / Inert atmosphere

3: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0 - 20 °C

4: sodium periodate; ruthenium(III) trichloride hydrate / tetrachloromethane; water; acetonitrile / 16 h / 20 °C

With 1H-imidazole; dmap; sodium periodate; ruthenium(III) trichloride hydrate; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2011.07.049

Reference yield:

: 1337862-59-5
(S)-tert-butyl 1-cyclohexyl-2-oxopent-4-enylcarbamate

: 1337862-74-4
(2S,3R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-cyclohexyl-5-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium tri-t-butoxyaluminum hydride / ethanol / 2 h / -78 °C / Inert atmosphere

2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0 - 20 °C

3: sodium periodate; ruthenium(III) trichloride hydrate / tetrachloromethane; water; acetonitrile / 16 h / 20 °C

With 1H-imidazole; dmap; sodium periodate; ruthenium(III) trichloride hydrate; lithium tri-t-butoxyaluminum hydride; In tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2011.07.049