2,3-Pyrazinedicarbonitrile,5-(hydroxymethyl)-6-methyl-(9CI)

Base Information

• Chemical Name: 2,3-Pyrazinedicarbonitrile,5-(hydroxymethyl)-6-methyl-(9CI)
• CAS No.: 192933-53-2
• Molecular Formula: C₈H₆N₄O
• Molecular Weight: 174.162
• Mol file: 192933-53-2.mol

Synonyms:2,3-Pyrazinedicarbonitrile,5-(hydroxymethyl)-6-methyl-(9CI);5-(HYDROXYMETHYL)-6-METHYLPYRAZINE-2,3-DICARBONITRILE

Chemical Property of 2,3-Pyrazinedicarbonitrile,5-(hydroxymethyl)-6-methyl-(9CI)

Chemical Property:

• PSA: 93.59000
• LogP: 0.02066

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Pyrazinedicarbonitrile,5-(hydroxymethyl)-6-methyl-(9CI)

There total 1 articles about 2,3-Pyrazinedicarbonitrile,5-(hydroxymethyl)-6-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

glycolic Acid (79-14-1) + 5-methylpyrazine-2,3-dicarbonitrile (52197-12-3) → 2,3-dicyano-6-hydroxymethyl-5-methylpyrazine (192933-53-2)

Guidance literature:

With ammonium peroxydisulfate; silver nitrate; In acetonitrile; for 5h; Heating;

DOI:10.1002/jhet.5570340341

Reference yield:

2,3-dicyano-6-hydroxymethyl-5-methylpyrazine (192933-53-2) → 5-(N-phenylimino)methenyl-6-methylpyrazine-2,3-dicarbonitrile (192933-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / MnO₂ / CH₂Cl₂ / 22 h / Ambient temperature

2: 65 percent / 4 Angstroem sieves, AcOH / ethanol / 4 h

With manganese(IV) oxide; 4 A molecular sieve; acetic acid; In ethanol; dichloromethane;

DOI:10.1002/jhet.5570340341

Reference yield:

2,3-dicyano-6-hydroxymethyl-5-methylpyrazine (192933-53-2) → 5-Methyl-3-methylamino-6-[(E)-phenyliminomethyl]-pyrazine-2-carbonitrile (192933-56-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / MnO₂ / CH₂Cl₂ / 22 h / Ambient temperature

2: 65 percent / 4 Angstroem sieves, AcOH / ethanol / 4 h

3: 65 percent / Et₃N / tetrahydrofuran / 7 h / Ambient temperature

With manganese(IV) oxide; 4 A molecular sieve; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/jhet.5570340341

upstream raw materials:

glycolic Acid

5-methylpyrazine-2,3-dicarbonitrile

Downstream raw materials:

2,3-dicyano-5-methyl-6-(p-tolylimino)methylpyrazine

3-allylamino-2-cyano-6-(mesitylamino)methyl-5-methylpyrazine

5-(N-phenylimino)methenyl-6-methylpyrazine-2,3-dicarbonitrile

5-Methyl-3-methylamino-6-[(E)-phenyliminomethyl]-pyrazine-2-carbonitrile

Refernces