10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

Base Information

Chemical Name:10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide
CAS No.:1287794-60-8
Molecular Formula:C₁₉H₁₈F₃IN₂O₅S
Molecular Weight:570.328
Hs Code.:

10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

Synonyms:10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

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Chemical Property of 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

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Technology Process of 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

There total 8 articles about 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (Z)-10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-4,7-dihydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

: 1287794-60-8
10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2016.12.014

Reference yield: 74.0%

: 1287794-53-9
C₁₉H₁₆F₃IN₂O₃S

: 1287794-60-8
10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

Guidance literature:: With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

: 1287794-78-8
benzene, 1,2,3-trifluoro-4-nitro-5-(2-propen-1-yloxy)

: 1287794-60-8
10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 17 h / -78 - 20 °C

2.1: water; sodium dithionite / ethanol / 1 h / 90 °C

3.1: 20 °C / Inert atmosphere; Heating

4.1: Hoveyda-Grubbs catalyst second generation / 1,1-dichloroethane / 3 h / 70 °C

5.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 14 h / 20 °C

With osmium(VIII) oxide; sodium dithionite; water; 4-methylmorpholine N-oxide; lithium hexamethyldisilazane; Hoveyda-Grubbs catalyst second generation; In tetrahydrofuran; 1,1-dichloroethane; ethanol;