tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-03-0
Molecular Formula:C₂₆H₃₁F₃N₄O₆S
Molecular Weight:584.617
Hs Code.:

Synonyms:tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 17 articles about tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1589535-17-0
C₁₆H₁₉F₃N₂O₂

: 1572928-03-0
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: C₁₆H₁₉F₃N₂O₂; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm5000497

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1572928-03-0
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.67 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: water / 1,4-dioxane / 24 h / 85 °C

3.1: toluene-4-sulfonic acid / acetone / 40 h / 20 °C

4.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

5.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

With trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; water; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; acetone;

Reference yield:

: 1450620-13-9
benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1572928-03-0
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

2: trifluoroacetic acid; trifluorormethanesulfonic acid / 1.5 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 20 °C

With trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); triethylamine; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane;