(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate
CAS No.:1376190-88-3
Molecular Formula:C₂₆H₂₈ClNO₄
Molecular Weight:453.966
Hs Code.:

Synonyms:(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

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Chemical Property of (S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

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Technology Process of (S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

There total 4 articles about (S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1376190-83-8
ethyl 4-(4-chlorophenyl)-3-phenyl-1H-pyrrole-2-carboxylate

: 67987-67-1,98095-37-5,104596-85-2
(4S)-4-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolane

: 1376190-88-3
(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm300178u

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 1376190-88-3
(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u

Reference yield:

: 100-52-7
benzaldehyde

: 1376190-88-3
(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-phenyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u