3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

Base Information

Chemical Name:3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran
CAS No.:1160457-39-5
Molecular Formula:C₃₄H₃₀O₆
Molecular Weight:534.609
Hs Code.:

Synonyms:3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

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Chemical Property of 3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

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Technology Process of 3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

There total 6 articles about 3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1160457-37-3
1-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-3-phenylprop-2-yn-1-ol

: 824-94-2
p-methoxybenzyl chloride

: 1160457-39-5
3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

Guidance literature:: 1-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-3-phenylprop-2-yn-1-ol; With potassium hydride; In tetrahydrofuran; Inert atmosphere;

p-methoxybenzyl chloride; With sodium iodide; In tetrahydrofuran; at 45 ℃; for 2h; Inert atmosphere;

Reference yield:

: 108-73-6
3,5-dihydroxyphenol

: 1160457-39-5
3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / diethyl ether / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 112 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 0.5 h / Reflux; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: 4-methyl-morpholine; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; osmium(VIII) oxide; n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol; 1.1: Hoesch reaction;
DOI:10.1021/jo202366c

Reference yield:

: 1160457-28-2
4,6-dimethoxy-2-(4-methoxyphenyl)-3-vinylbenzofuran

: 1160457-39-5
3-(1-(4-methoxybenzyloxy)-3-phenylprop-2-ynyl)-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; osmium(VIII) oxide; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;
DOI:10.1021/jo202366c