3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

Base Information

Chemical Name:3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline
CAS No.:1567951-19-2
Molecular Formula:C₂₄H₂₈N₄O₂S
Molecular Weight:436.578
Hs Code.:

Synonyms:3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

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Chemical Property of 3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

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Technology Process of 3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

There total 6 articles about 3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 22948-02-3
3-aminothiophenol

: 1567951-16-9
1-(5-iodo-6-((4-methoxybenzyl)oxy)pyridin-2-yl)-4-methylpiperazine

: 1567951-19-2
3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

Guidance literature:: With copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm401552y

Reference yield:

: 40473-07-2
6-bromo-2-methoxypyridine

: 1567951-19-2
3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 130 °C

2: tetrabutylammomium bromide; hydrogen bromide / water / Reflux; Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

4: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 1 h / 20 °C / Inert atmosphere

5: 2.9-dimethyl-1,10-phenanthroline; copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; tetrabutylammomium bromide; hydrogen bromide; sodium hydride; potassium carbonate; trifluoroacetic acid; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401552y

Reference yield:

: 1033752-64-5
1-(6-methoxypyridin-2-yl)-4-methylpiperazine

: 1567951-19-2
3-((2-((4-methoxybenzyl)oxy)-6-(4-methylpiperazin-1-yl)pyridin-3-yl)thio)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; hydrogen bromide / water / Reflux; Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 1 h / 20 °C / Inert atmosphere

4: 2.9-dimethyl-1,10-phenanthroline; copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; tetrabutylammomium bromide; hydrogen bromide; sodium hydride; potassium carbonate; trifluoroacetic acid; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401552y