1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

Base Information

Chemical Name:1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide
CAS No.:929210-09-3
Molecular Formula:C₂₉H₄₇N₅O₅
Molecular Weight:545.723
Hs Code.:

1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

Synonyms:1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

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Chemical Property of 1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

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Technology Process of 1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

There total 4 articles about 1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 929210-06-0
1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 929210-09-3
1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetasy.2006.12.006

Reference yield:

: (R)-1-((S)-2-Amino-3-methyl-butyryl)-4-methylene-pyrrolidine-2-carboxylic acid ethyl ester

: 929210-09-3
1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 80 percent / NaOH / ethanol / 20 °C

3: 83 percent / 4-(4,6-(MeO)2-1,3,5-triazin-2-yl)-4-Me-morpholinium chloride / tetrahydrofuran / 20 °C

With sodium hydroxide; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tetasy.2006.12.006

Reference yield:

: 908299-17-2
(2R,5S)-(6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid pentafluorophenyl ester

: 929210-09-3
1-{2(S)-[2-(6-ethoxy-5(S)-isopropyl-2(R)-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetylamino]-3-methyl-butyryl}-4-methylene-pyrrolidine-2(R)-carboxylic acid cyclohexyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 80 percent / NaOH / ethanol / 20 °C

3: 83 percent / 4-(4,6-(MeO)2-1,3,5-triazin-2-yl)-4-Me-morpholinium chloride / tetrahydrofuran / 20 °C

With sodium hydroxide; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tetasy.2006.12.006