Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

Base Information

Chemical Name:Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane
CAS No.:910789-63-8
Molecular Formula:C₅₁H₈₀O₆S₂Si
Molecular Weight:881.41
Hs Code.:

Synonyms:Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

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Chemical Property of Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

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Technology Process of Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

There total 1 articles about Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 100-39-0
benzyl bromide

: 609355-76-2
(2R,3S,4R,6R)-4,8-Bis-benzyloxy-1-[2-((1S,3R)-1,3-dimethyl-4-triisopropylsilanyloxy-butyl)-[1,3]dithian-2-yl]-3-methoxymethoxy-6-methyl-octan-2-ol

: 910789-63-8
Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 0.666667h;
DOI:10.1021/ol0613766

Reference yield: 99.0%

: 910789-63-8
Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

: 910789-64-9
(2R,4S)-2-Methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1021/ol0613766

Reference yield:

: 910789-63-8
Triisopropyl-{(2R,4S)-2-methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyloxy}-silane

: 910789-48-9
{(2R,4S)-2-Methyl-4-[2-((2R,3R,4R,6R)-2,4,8-tris-benzyloxy-3-methoxymethoxy-6-methyl-octyl)-[1,3]dithian-2-yl]-pentyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / TBAF / tetrahydrofuran / 2.5 h / 20 °C

2: 100 percent / triphenylphosphine; diethyl azodicarboxylate / benzene / 0.42 h / 20 °C

3: 86 percent / triethylamine; DMAP / CH₂Cl₂ / 14 h / 20 °C

4: 72 percent / 2-mercaptoethanol; DBU / acetonitrile / 1.17 h / 0 °C

With dmap; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; 2-hydroxyethanethiol; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol0613766