Technology Process of C35H38N4O5
There total 6 articles about C35H38N4O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C34H41N3O6;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -60 ℃;
for 1h;
With
triethylamine;
In
dichloromethane;
at -60 ℃;
for 0.25h;
trimethylsilyl cyanide;
With
zinc(II) chloride;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/jo200553g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane / 5 h / 0 - 20 °C
2.1: acetic acid / dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 °C
5.2: 0.25 h / -60 °C
5.3: 2 h / 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; acetic acid; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
2.1: Pictet-Spengler cyclisation / 5.1: Swern oxidation / 5.2: Swern oxidation;
DOI:10.1021/jo200553g
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C
2.1: dichloromethane / 5 h / 0 - 20 °C
3.1: acetic acid / dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 °C
6.2: 0.25 h / -60 °C
6.3: 2 h / 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
3.1: Pictet-Spengler cyclisation / 6.1: Swern oxidation / 6.2: Swern oxidation;
DOI:10.1021/jo200553g
