1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

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Chemical Name:1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate
CAS No.:1258855-47-8
Molecular Formula:C₂₉H₃₃N₅O₅
Molecular Weight:531.612
Hs Code.:

Synonyms:1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

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Chemical Property of 1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

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Technology Process of 1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

There total 13 articles about 1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4530-20-5
BOC-glycine

: 1258855-37-6
2-[(1-methylethyl)oxy]-5-[3-(5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

: 1258855-47-8
1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

Guidance literature:: BOC-glycine; With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.0333333h;

2-[(1-methylethyl)oxy]-5-[3-(5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258855-47-8
1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: pyridine / toluene / 15.33 h / 20 - 80 °C

3.1: hydrogenchloride / 1,4-dioxane / 5.5 h / 20 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.03 h

4.2: 20 °C

With N-ethylmorpholine;; pyridine; hydrogenchloride; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1165923-89-6
1,1-dimethylethyl 6-hydroxy-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1258855-47-8
1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / -30 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 28.5 h / Reflux

4.1: pyridine / toluene / 15.33 h / 20 - 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 5.5 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.03 h

6.2: 20 °C

With N-ethylmorpholine;; pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;