Technology Process of 1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate
There total 13 articles about 1,1-dimethylethyl {2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-2-oxoethyl}carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
BOC-glycine;
With
N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
for 0.0333333h;
2-[(1-methylethyl)oxy]-5-[3-(5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C
2.1: pyridine / toluene / 15.33 h / 20 - 80 °C
3.1: hydrogenchloride / 1,4-dioxane / 5.5 h / 20 °C / Inert atmosphere
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.03 h
4.2: 20 °C
With
N-ethylmorpholine;; pyridine; hydrogenchloride; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
N,N-dimethyl-formamide;
In
1,4-dioxane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / dichloromethane / -30 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 28.5 h / Reflux
4.1: pyridine / toluene / 15.33 h / 20 - 80 °C
5.1: hydrogenchloride / 1,4-dioxane / 5.5 h / 20 °C / Inert atmosphere
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.03 h
6.2: 20 °C
With
N-ethylmorpholine;; pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
