Technology Process of 6-O-benzoylfumagillol
There total 16 articles about 6-O-benzoylfumagillol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1248/cpb.40.96
- Guidance literature:
-
Multi-step reaction with 15 steps
1: Br2, KHMDS / diethyl ether / -78 °C
2: 1.) O3, 2.) Ph3P
3: KOH
4: 1.) t-BuLi, Bu3SnLi, 3.) n-BuLi, CuCN,
6: MCPBA
7: TBAF, NH4Cl
8: Ag2O
9: L-selectride
11: H2O, H(+)
12: 1.) NaIO4, 2.) <(Me)3S=O>(+), NaH
13: 77 percent / MCPBA
14: Dess-Martin
With
potassium hydroxide; sodium periodate; n-butyllithium; tri-n-butyltin lithium; trimethylsulfoxonium ion; tetrabutyl ammonium fluoride; water; bromine; tert.-butyl lithium; hydrogen cation; potassium hexamethylsilazane; L-Selectride; sodium hydride; ammonium chloride; Dess-Martin periodane; ozone; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; silver(l) oxide;
In
diethyl ether;
DOI:10.1021/ja990784k
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 1.) O3, 2.) Ph3P
2: KOH
3: 1.) t-BuLi, Bu3SnLi, 3.) n-BuLi, CuCN,
5: MCPBA
6: TBAF, NH4Cl
7: Ag2O
8: L-selectride
10: H2O, H(+)
11: 1.) NaIO4, 2.) <(Me)3S=O>(+), NaH
12: 77 percent / MCPBA
13: Dess-Martin
With
potassium hydroxide; sodium periodate; n-butyllithium; tri-n-butyltin lithium; trimethylsulfoxonium ion; tetrabutyl ammonium fluoride; water; tert.-butyl lithium; hydrogen cation; L-Selectride; sodium hydride; ammonium chloride; Dess-Martin periodane; ozone; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; silver(l) oxide;
DOI:10.1021/ja990784k
